Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
- Creator: Keaton, Jacob M. , Kamali, Zoha , Young, William J. , Lehtimäki, T , Raitakari, OT , Johnson, AD , Newton-Cheh, C , Brown, MJ , Dominiczak, AF , Sever, PJ , Poulter, N , Chambers, JC , Elosua, R , Traylor, Matthew , Siscovick, D , Esko, T , Metspalu, A , Strawbridge, RJ , Laakso, M , Hamsten, A , Hottenga, J-J , de Geus, E , Morris, AD , Palmer, CNA , Giri, Ayush , Nolte, IM , Milaneschi, Y , Marten, J , Wright, A , Zeggini, E , Howson, JMM , O'Donnell, CJ , Spector, T , Nalls, MA , Simonsick, EM , Zheng, Zhili , Liu, Y , van Duijn, CM , Butterworth, AS , Danesh, JN , Menni, C , Wareham, NJ , Khaw, K-T , Sun, YV , Wilson, PWF , Cho, K , Zeng, Jian , Visscher, PM , Denny, JC , Million Veteran Program, , Lifelines Cohort Study, , CHARGE consortium, , ICBP Consortium, , Levy, D , Edwards, TL , Munroe, PB , Snieder, H , Chasman, Daniel I. , Warren, HR , Morris, Andrew P. , Caulfield, Mark J. , Hwang, Shih-Jen , Kooner, Jaspal S. , Xie, Tian , Attia, John R. , Attia, JR , Morrison, AC , Loos, RJF , Kristiansson, K , Schmidt, R , Hicks, AA , Pramstaller, PP , Nelson, CP , Samani, NJ , Vaez, Ahmad , Risch, L , Gyllensten, U , Melander, O , Riese, H , Wilson, JF , Campbell, H , Rich, SS , Psaty, BM , Lu, Y , Rotter, JI , Williams, Ariel , Guo, X , Rice, KM , Vollenweider, P , Sundström, J , Langenberg, C , Tobin, MD , Giedraitis, V , Luan, J , Tuomilehto, J , Kutalik, Z , Goleva, Slavina B. , Ripatti, S , Salomaa, V , Girotto, G , Trompet, S , Jukema, JW , van der Harst, P , Ridker, PM , Giulianini, F , Vitart, V , Goel, A , Ani, Alireza , Watkins, H , Harris, SE , Deary, IJ , van der Most, PJ , Oldehinkel, AJ , Keavney, BD , Hayward, C , Campbell, A , Boehnke, M , Scott, LJ , Evangelou, Evangelos , Boutin, T , Mamasoula, C , Järvelin, M-R , Peters, A , Gieger, C , Lakatta, EG , Cucca, F , Hui, J , Knekt, P , Enroth, S , Hellwege, Jacklyn N. , De Borst, MH , Polašek, O , Concas, MP , Catamo, E , Cocca, M , Li-Gao, R , Hofer, E , Schmidt, H , Spedicati, B , Waldenberger, M , Yengo, Loic , Strachan, DP , Laan, M , Teumer, A , Dörr, M , Gudnason, V , Cook, JP , Ruggiero, D , Kolcic, I , Boerwinkle, E , Traglia, M
- Resource Type: journal article
- Date: 2024
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
- Creator: Schmidt, Amand F. , Holmes, Michael V. , Preiss, David , Swerdlow, Daniel I. , Denaxas, Spiros , Fatemifar, Ghazaleh , Faraway, Rupert , Finan, Chris , Valentine, Dennis , Fairhurst-Hunter, Zammy , Hartwig, Fernando Pires , Horta, Bernardo Lessa , Hypponen, Elina , Power, Christine , Moldovan, Max , van Iperen, Erik , Hovingh, Kees , Demuth, Ilja , Norman, Kristina , Steinhagen-Thiessen, Elisabeth , Hancock, Stephen , Attia, John , Holliday, Elizabeth , Scott, Rodney , Teumer, A , Baumeister, S , Doerr, M , Lerch, MM , Voelker, U , Voelzke, H , Ward, J , Pell, JP , Meade, T , Christophersen, IE , Maitland-van der Zee, AH , Baranova, EV , Young, R , Ford, I , Campbell, A , Padmanabhan, S , Bots, ML , Grobbee, DE , Froguel, P , Thuillier, D , Roussel, R , Bonnefond, A , Cariou, B , Smart, M , Bao, Y , Kumari, M , Mahajan, A , Hopewell, JC , Seshadri, S , Dale, C , Costa, RPE , Ridker, PM , Chasman, DI , Reiner, AP , Ritchie, MD , Lange, LA , Cornish, AJ , Dobbins, SE , Hemminki, K , Kinnersley, B , Sanson, M , Labreche, K , Simon, M , Bondy, M , Law, P , Speedy, H , Allan, J , Li, N , Went, M , Weinhold, N , Morgan, G , Sonneveld, P , Nilsson, B , Goldschmidt, H , Sud, A , Engert, A , Hansson, M , Hemingway, H , Asselbergs, FW , Patel, RS , Keating, BJ , Sattar, N , Houlston, R , Casas, JP , Hingorani, AD , Demuth, Juri , Bertram, L , Lill, CM , Coassin, S , Willeit, J , Kiechl, S , Willeit, K , Mason, D , Wright, J , Morris, R , Wanamethee, G , Whincup, P , Ben-Shlomo, Y , McLachlan, S , Price, JF , Kivimaki, M , Welch, C , Sanchez-Galvez, A , Marques-Vidal, P , Nicolaides, A , Panayiotou, AG , Onland-Moret, NC , van der Schouw, YT , Matullo, G , Fiorito, G , Guarrera, S , Sacerdote, C , Wareham, NJ , Langenberg, C , Scott, RA , Luan, J , Bobak, M , Malyutina, S , Pajak, A , Kubinova, R , Tamosiunas, A , Pikhart, H , Grarup, N , Pedersen, O , Hansen, T , Linneberg, A , Jess, T , Cooper, J , Humphries, SE , Brilliant, M , Kitchner, T , Hakonarson, H , Carrell, DS , McCarty, CA , Lester, KH , Larson, EB , Crosslin, DR , de Andrade, M , Roden, DM , Denny, JC , Carty, C , Schofield, P , O'Donnell, M , Yusuf, S , Chong, M , Pare, G , van der Harst, P , Said, MA , Eppinga, RN , Verweij, N , Snieder, H , Christen, T , Mook-Kanamori, DO , Gustafsson, S , Lind, L , Ingelsson, E , Pazoki, R , Franco, O , Hofman, A , Uitterlinden, A , Dehghan, A
- Resource Type: journal article
- Date: 2019
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
- Creator: Justice, Anne E. , Karaderi, Tugce , Highland, Heather M. , Young, Kristin L. , Graff, Mariaelisa , Lu, Yingchang , Turcot, Valérie , Auer, Paul L. , Fine, Rebeccaa S. , Guo, Xiuqing , Schurmann, Claudia , Lempradl, Adelheid , Marouli, Eirini , Mahajan, Anubha , Winkler, Thomas W. , Locke, Adam E. , Medina-Gomez, Carolina , Esko, Tõnu , Vedantam, Sailaja , Giri, Ayush , Pennell, Craig E. , Wang, Carol A. , Lo, Ken Sin , Alfred, T , Mudgal, P , Ng, MCY , Heard-Costa, NL , Feitosa, MF , Manning, AK , Willems, SM , Sivapalaratnam, S , Abecasis, G , Alam, DS , Allison, M , Amouyel, P , Arzumanyan, Z , Balkau, B , Bastarache, L , Bergmann, S , Bielak, LF , Blüher, M , Boehnke, M , Boeing, H , Boerwinkle, E , Böger, CA , Bork-Jensen, J , Bottinger, EP , Bowden, DW , Brandslund, I , Broer, L , Burt, AA , Butterworth, AS , Caulfield, MJ , Cesana, G , Chambers, JC , Chasman, DI , Chen, YDI , Chowdhury, R , Christensen, C , Chu, AY , Collins, FS , Cook, JP , Cox, AJ , Crosslin, DS , Danesh, J , de Bakker, PIW , Denus, SD , Mutsert, RD , Dedoussis, G , Demerath, EW , Dennis, JG , Denny, JC , Angelantonio, ED , Dörr, M , Drenos, F , Dubé, MP , Dunning, AM , Easton, DF , Elliott, P , Evangelou, E , Farmaki, AE , Feng, S , Ferrannini, E , Ferrieres, J , Florez, JC , Fornage, M , Fox, CS , Franks, PW , Friedrich, N , Gan, W , Gandin, I , Gasparini, P , Giedraitis, V , Girotto, G , Gorski, M , Grallert, H , Grarup, N , Grove, ML , Gustafsson, S , Haessler, J , Hansen, T , Hattersley, AT
- Resource Type: journal article
- Date: 2019
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
- Creator: Giri, Ayush , Hellwege, Jacklyn N. , Keaton, Jacob M. , Park, Jihwan , Qiu, Chengxiang , Warren, Helen R. , Torstenson, Eric S. , Kovesdy, Csaba P. , Sun, Yan V. , Wilson, Otis D. , Robinson-Cohen, Cassianne , Roumie, Christianne L. , Chung, Cecilia P. , Birdwell, Kelly A. , Damrauer, Scott M. , DuVall, Scott L. , Klarin, Derek , Cho, Kelly , Wang, Yu , Evangelou, Evangelos , Attia, John , Oldmeadow, Christopher , Wei, WQ , Jarvelin, MR , Hennig, BJ , Timpson, NJ , Smith, JC , Xu, Y , Matheny, ME , Siew, EE , Lindgren, C , Herzig, KH , Dedoussis, G , Denny, JC , Psaty, BM , Howson, JMM , Munroe, PB , Newton-Cheh, C , Caulfield, MJ , Elliott, P , Gaziano, JM , Concato, J , Wilson, PWF , Tsao, PS , Velez Edwards, DR , Susztak, K , O¿Donnell, CJ , Hung, AM , Edwards, TL , Cabrera, Claudia P. , Wain, LV , Shrestha, R , Mautz, BS , Akwo, EA , Sargurupremraj, M , Debette, S , Boehnke, M , Scott, LJ , Luan, J , Zhao, JH , Willems, SM , Thériault, S , Shah, N , Almgren, P , Li-Gao, R , Verweij, N , Boutin, TS , Mangino, M , Ntalla, I , Feofanova, E , Surendran, P , Cook, JP , Karthikeyan, S , Lahrouchi, N , Liu, C , Sepúlveda, N , Richardson, TG , Kraja, A , Amouyel, P , Farrall, M , Poulter, NR , Laakso, M , Zeggini, E , Sever, P , Scott, RA , Langenberg, C , Wareham, NJ , Conen, D , Palmer, CNA , Chasman, DI , Ridker, PM , Melander, O , Mook-Kanamori, DO , van der Harst, P , Cucca, F , Schlessinger, D , Hayward, C , Spector, TD
- Resource Type: journal article
- Date: 2019